Christian Hummert
Personal Data:
Country of Origin: Germany
Start of PhD: March 2006
PhD Project:
Error Correction for the Integration of Proteome and
Transcriptome data
Project Leader: PD. Dr. Reinhard Guthke
Abstract:
The problem of integrating proteome and transcriptome data is
not well
solved. One main
problem is that both data is afflicted with high error. In transcriptome
data it is at least possible
to estimate the error due the design of the microarray chips.
For proteome
date the situation is
worse, the 2-D gel electrophoresis gels are difficult to analyse
and
evaluate.
On the other side there are many heuristic algorithms in
computerscience,
e.g. neural
networks which can handle unsharp data, and evaluate them. The
goal is to
create an
automatic error predictor for an integrated proteome and
transcriptome
analysis.
Publications:
- Huber R, Hummert C, Gausmann U, Koczan D, Guthke R, Kinne RW (2008)
Identification of inter-individual and gene-specific variances in mRNA expression
profiles in the rheumatoid arthritis synovial membrane. Arthritis Res Ther 10, R98.
- Hummert C, Menger G (2005) New Programming Language
Concepts for Confidentiality. PLC, 158-164.
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