C4 - PD Dr. Reinhard Guthke
Bioinformatics Tools for the Recognition and Modeling of Biomolecular Networks

Abstract:
Network models for the regulation of genes, proteins, and/or metabolites are important to understand the processing in such networks. This knowledge is desired, for example, to obtain control over pathomechanisms such as a fungal infection by Aspergillus fumigatus. For the computer-assisted construction of dynamic network models new methods have to be developed. These methods are directed to several tasks: i) pattern recognition in transcriptome, proteome, or metabolome data as well as data from biochemical and microbiological assays, ii) structure and parameter optimization of dynamic system models in a reverse engineering approach, and iii) integration of available microbiological and molecular biological knowledge into the data analysis and modeling stages.

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