Prof. Dr. Hans Peter Saluz
Molecular study of apoptotic processes in Aspergillus ssp. and the
influence of Aspergillus fumigatus on apoptosis of host immune effector
cells
Abstract:
Previous results suggest that some potent fungicidals induce a type
of apoptosis in A. nidulans similar to the caspase-independent apoptosis
observed in mammalian systems. Therefore, we aim at the molecular
elucidation of such events in Aspergillus ssp. using most
modern technologies like parallel Rapid PCR, chip/array approaches
or MALDI-TOF/TOF and others. Furthermore, we plan to investigate
molecular mechanisms of how Aspergillus fumigatus suppresses
the human cellular immune response via apoptosis of immune effector
cells.
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