Sebastian Müller

Personal Data:
Country of Origin: Germany
Start of PhD: May 2009
Institution: HKI

PhD Project:
Integrated genome-wide data analysis by ensemble learning methods to understand infection processes

Supervisor(s): R. Guthke (HKI)

Abstract:
Transcription analysis can be a valuable approach to better understand regulatory processes and complex gene-protein interaction-networks. To explore such a transcriptome, data from two state of the art methods, namely microarray-analysis and next-generation-sequenciEnsemble techniques, will be analysed and compared by means of supervised and unsupervised ensemble learning methods.
In particular, such an analysis will be performed to understand infection processes and virulence of Aspergillus fumigatus by gene expression analysis of infected murine macrophages.

Publication:

• Müller S, Fleck CB, Wilson D, Hummert C, Hube B, Brock M (2011): Gene acquisition, duplication and metabolic specification: The evolution of fungal methylisocitrate lyases. Eviron Microbiol, 13(6):1534-48. doi: 10.1111/j.1462-2920.2011.02458.x